Resources for Pharmacy Compounding, Sterile Drug Preparation, and Hazardous Drug Preparation
Over a decade ago, the United States Pharmacopeia issued Chapter 797 "Pharmaceutical Compounding – Sterile Preparations" (USP <797>), which provides the guidelines, procedures and compliance requirements for compounding sterile preparations and sets the standards that apply to all settings in which sterile preparations are compounded. With the addition of USP <800> "Hazardous Drugs – Handling in Healthcare Settings," this resource center has been prepared to help you stay current on the latest issues about aseptic preparation of parenteral hazardous and non-hazardous drug products.
Surface contamination with antineoplastic agents in six cancer treatment centers in Canada and the United States.
This study provides evidence from a sample of facilities indicating that antineoplastic agents were detected on surfaces in pharmacy drug preparation and administration areas in cancer treatment centers, and includes a brief overview of the potential risks of exposure.
Wenzel R. Edmond M; The Impact of Hospital-Acquired Bloodstream Infections: Emerging Infectious Diseases, Vol. 7 No. 2, March-April 2001
This report assesses the scope and cost of bloodstream infections in the hospital, underscoring the importance of maintaining sterile conditions during preparation.
Cazin JL, Gosselin P; Implementing a Multiple-isolator Unit for Centralized Preparation of Cytotoxic Drugs in a Cancer Center Pharmacy; Pharm World Sci 1999 Aug;21(4):177-83
Another case study, this article details the selection process of equipment for an area within the pharmacy for the preparation of cytotoxic drugs. In addition to explaining the reasons for use of barrier isolators, this article also underscores the importance of a safety and quality standards.
Tillet, L; Barrier Isolators as an Alternative to a Cleanroom; Am J Health Syst Pharm 1999 Jul 15;56(14):1433-6
This case study uses barrier isolators to insure sterility and containment in the preparation of cytotoxic and other hazardous agents. Relative to a cleanroom, the analysis found a reduction in costs attributable to reduced gown and glove use.