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SREBP Coordinates Iron and Ergosterol Homeostasis to Mediate Triazole Drug and Hypoxia Responses in the Human Fungal Pathogen Aspergillus fumigatus

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Michael Blatzer, Bridget M. Barker, Sven D. Willger, Nicola Beckmann, Sara J. Blosser, Elizabeth J. Cornish, Aurelien Mazurie, Nora Grahl, Hubertus Haas, Robert A. Cramer

Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability

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David R. Wise, Patrick S. Ward, Jessica E. S. Shay, Justin R. Cross, Joshua J. Gruber, Uma M. Sachdeva, Jesse M. Platt, Raymond G. DeMatteo, M. Celeste Simon, and Craig B. Thompson

HacA-Independent Functions of the ER Stress Sensor IreA Synergize with the Canonical UPR to Influence Virulence Traits in Aspergillus fumigatus

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Xizhi Feng, Karthik Krishnan, Daryl L. Richie, Vishukumar Aimanianda, Lukas Hartl, Nora Grahl, Margaret V. Powers-Fletcher, Minlu Zhang, Kevin K. Fuller, William C. Nierman, Long Jason Lu, Jean-Paul Latgé, Laura Woollett, Simon L. Newman, Robert A. Cramer, Judith C. Rhodes, David S. Askew

Pronounced Hypoxia in Models of Murine and Human Leukemia: High Efficacy of Hypoxia-Activated Prodrug PR-104

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Juliana Benito, Yuexi Shi, Barbara Szymanska, Hernan Carol, Ingrid Boehm, Hongbo Lu, Sergej Konoplev, Wendy Fang, Patrick A. Zweidler-McKay, Dario Campana, Gautam Borthakur, Carlos Bueso-Ramos, Elizabeth Shpall, Deborah A. Thomas, Craig T. Jordan, Hagop Kantarjian, William R. Wilson, Richard Lock, Michael Andreeff, Marina Konopleva